Nyong'o's parents are Dorothy and Peter Anyang' Nyong'o, a politician. Peter was the former Kenyan Minister for Medical Services. At the time of Lupita's birth, he was a visiting lecturer in political science. He was elected in 2013 to represent Kisumu County in the Kenyan Senate. Her cousin Isis Nyong'o was named one of Africa's most powerful women by Forbes magazine in 2012.
Nyong'o moved back to Kenya when she was less than one year old, when her father was hired as a professor at the University of Nairobi. At age sixteen, her parents sent her back to Mexico for a few months to learn Spanish.
Nyong'o currently lives in Brooklyn, New York with her brother.
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